Hsieh got off to a slow start to the summer hard-court season. She played just one tournament between the Olympics and the US Open, the Texas Tennis Open. In singles, she was beaten by eventual champion Roberta Vinci in the first round, while falling in the quarterfinals of the doubles tournament with partner Gabriela Dabrowski to Iveta Benešová and Barbora Záhlavová-Strýcová. At the US Open, she suffered a three set loss in singles to Magdaléna Rybáriková in the first round, but was successful in the women's doubles tournament with partner Anabel Medina Garrigues, where they reached the semifinals. Hsieh piled together a hugely successful Asian hard-court season following the Open, winning 17 of her last 21 matches. She won the Ningbo Challenger, a $100k tournament, defeating Zhang Shuai in the final. The next week, she reached the final at the Guangzhou International Open dropping just one set en route. Facing the 17-year old Brit Laura Robson, the silver medalist in mixed doubles with Andy Murray at the Olympics who had defeated both four-time Grand Slam Champion Kim Clijsters and 2011 French Open champion, Li Na, en route to the fourth round at the US Open less than a month earlier, Hsieh played the most intense tennis match of her life. Despite being 0–2 down in each of the first two sets, having five match points saved in the second set, the match being suspended after the second set due to the excruciatingly hot temperatures, and then being 0–3 down in the final set, she fought back to win the title in three sets by a score of 6–3, 5–7, 6–4. This marked Hsieh's second WTA singles title of the year, and with it she jumped into the top 50 of the singles rankings for the first time, at No. 39. Though her 10-match winning streak was snapped in her very next match at the Pan Pacific Open, she won another $100k ITF singles title two weeks later at the Suzhou Open, her 23rd career ITF singles title. This brought her into the top 25 for the first time, becoming the first Taiwanese tennis player to achieve a ranking that high. Hsieh concluded her season at the Tournament of Champions, where she was invited to compete for the first time. She lost her first two matches to Caroline Wozniacki and Vinci, but ended her year on a high note with a three set victory over Hantuchová. Hsieh finished with her best year-end ranking to date, world No. 25 in singles, a ranking which she equaled in doubles.

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